Over a long career of clinical practice, physician executive experience, and population health data analysis, I (and many others) have concluded that improved patient engagement and appropriate influence of physician decisions at the point of care have the largest impact on waste. That impact happens when patients are supported in making changes required to live a more healthy life, and when physicians and nurses as patients’ trusted advisors can guide patients with best evidence about the potential effectiveness and cost of a particular test and/or intervention. It is critical to embed support systems in both of these key areas, which are under-supported with accessible, relevant, and efficient tools.